GABA
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GABA Relieves Anxiety Feel ing of Well-Being Scientific Support The predominant effects of GHB are sedative. At low doses, GHB can relieve anxiety and produce relaxation – as the dose increases, however, the sedative effects result in sleep and eventual coma or death. GHB is one of a number of drugs implicated as “date rape” drugs for its effects as a central nervous system depressant. GHB also stimulates the release of growth hormone from the anterior pituitary gland – but no studies have ever shown GHB to result in positive changes in body fat levels, muscle mass or strength. Whether or not GHB works is sort of a moot point – as the FDA banned over-the-counter sale of GHB in 1990 – but it is still available in various forms (GBL, BD, furanone) in illegal dietary supplements and on the black market. Although GABA can be converted into GHB in the brain, and both appear to have power actions in certain regions of the brain, it is unclear whether orally administered GABA is converted to GHB. It does appear, however, that pituitary growth hormone release is partly regulated by blood levels of GABA. Many supplement marketers cite a single obscure Italian study as evidence that GABA increases growth hormone (GH) secretion in athletes. The study, which was conducted over 20 years ago, was carried out in fewer than 20 subjects, and while it did show an increase in blood levels of GH, it has yet to be replicated by other scientists. In more recent studies (in sheep), intravenous administration of GABA resulted in a rapid increase in plasma GH levels, while direct administration of GABA into the brain produced a significant increase in GH release. In other studies (in mice), increased concentrations of GABA in the systemic circulation have been linked to impaired liver repair. Safety: Although the chemical structure of GABA and GHB are similar, we are not aware of any adverse events associated with GABA-containing dietary supplements. GHB, however, is a far different story. Despite its presence in a wide variety of dietary supplements, the FDA considers it to be an illegal/unapproved drug – and not a supplement ingredient. As such, the FDA has moved to remove such products from the marketplace – and with good reason. GHB-containing products have been associated with a number of adverse side effects related to the dose of GHB. Low doses of GHB (0.5-1.5 grams) typically induce feelings of relaxation similar to mild alcohol intoxication, while medium doses (1-2.5 grams) increase muscle relaxation and cause physical disequilibrium and loss of coordination. High doses of GHB (above 2.5 grams) result in nausea, vomiting, and drowsiness as well as more serious adverse effects such as depressed breathing, bradycardia (slow heart rate), coma, and even death. Alcohol and other drugs with central nervous system depressant effects are known to compound the effect of GHB. **Toxic reactions have also been reported for supplement products containing GBL, BD and furanone. Details GABA (Gamma Aminobutyric Acid). GABA is an amino acid classified as a neurotransmitter. Studies have shown GABA to play a key role in the secretion of growth hormone. The principle anabolic actions of growth hormone include the stimulation of amino acid transport, stimulation of protein synthesis and the proliferation of cell growth. AST Sports Science selectively imports GABA under rigid quality control conditions. Each batch is HPLC Certified and Laboratory Tested for purity and potency. (Statements made have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.)

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